Methyl 2'-fluoro-2-(5-methyl-2-cyclopenten-1-yl)-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate → Methyl 2'-fluoro-2-(2-methylcyclopentyl)-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

HRID 1662455노트

반응식

HRID 1662455 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([O:18][CH3:19])=[O:17])=[CH:12][C:11]=1[CH:20]1[CH:24]([CH3:25])[CH2:23][CH:22]=[CH:21]1>[Pd].CCOC(C)=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([O:18][CH3:19])=[O:17])=[CH:12][C:11]=1[CH:20]1[CH2:21][CH2:22][CH2:23][CH:24]1[CH3:25]

참가 물질

4

반응물 1

HCID 57706603Methyl 2'-fluoro-2-(5-methyl-2-cyclopenten-1-yl)-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

생성물 1

HCID 57706176Methyl 2'-fluoro-2-(2-methylcyclopentyl)-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate수율 99.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A 100 mL round bottom flask was charged with 66.56F (mixture of diastereomers) (0.31 g, 0.91 mmol), EtOAc (10 mL), and Pd/C (10 wt. %) (0.097 g, 0.091 mmol). The mixture was purged three times with H2, stirred overnight under a H2 balloon, filtered through silica gel (EtOAc), and concentrated to afford 66.56G (mixture of diastereomers) (0.31 g, 99% yield) as a colorless oil.

후처리

  1. customThe mixture was purged three times with H2
  2. filtrationfiltered through silica gel (EtOAc)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7c56025a9b37400e8912be7fc040cbe9
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030354B2

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