2'-Fluoro-2-(1-hydroxy-2,2-dimethyl-but-3-enyl)-5'-methoxy-biphenyl-4-carboxylic acid methyl ester → Methyl 2'-fluoro-2-(1-hydroxy-2,2-dimethylbutyl)-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

HRID 1662459노트

반응식

HRID 1662459 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([O:18][CH3:19])=[O:17])=[CH:12][C:11]=1[CH:20]([OH:26])[C:21]([CH3:25])([CH3:24])[CH:22]=[CH2:23]>CO.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([O:18][CH3:19])=[O:17])=[CH:12][C:11]=1[CH:20]([OH:26])[C:21]([CH3:25])([CH3:24])[CH2:22][CH3:23]

참가 물질

4

반응물 1

HCID 574676322'-Fluoro-2-(1-hydroxy-2,2-dimethyl-but-3-enyl)-5'-methoxy-biphenyl-4-carboxylic acid methyl ester

생성물 1

HCID 57706901Methyl 2'-fluoro-2-(1-hydroxy-2,2-dimethylbutyl)-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate수율 86.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 66.60D (0.453 g, 1.26 mmol) in MeOH (10 mL) (degassed by N2), was added palladium on carbon (0.135 g, 1.26 mmol). The resulting mixture was stirred at room temperature under H2 for 18 hrs. The reaction mixture was then filtered through silica gel. After removing solvent, 66.62A (394 mg) was obtained as a colorless oil.

후처리

  1. filtrationThe reaction mixture was then filtered through silica gel
  2. customAfter removing solvent

출처 및 근거

ORD 기록
ord-c278b60e77d04d789c80177872c9efbf
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030354B2

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