참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cyclopentane, methylene- | HCID 73714 | — |
| 반응물 | Methyl 4-(allyloxy)benzoate | HCID 4645407 | — |
| 촉매 | (1,3-Bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene)(dichloro)((2-((propan-2-yl)oxy)phenyl)methylidene)ruthenium | HCID 11763533 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl 4-(2-cyclopentylideneethoxy)benzoate | HCID 57467652 | 68% |
반응 단계
To a solution of methyl 4-(allyloxy)benzoate 66.67A (3.00 g, 16.0 mmol) and methylenecyclopentane (1.9 g, 23.0 mmol) in DCM (5.0 mL) was added Hoveyda Grubbs reagent (0.39 g, 0.62 mmol) at room temperature. The resulting reaction mixture was degassed three times and stirred at 55° C. under nitrogen overnight. The reaction mixture was purified by Combi Flash silica gel chromatography (hexane/EtOAc 95/5) to give the compound 66.67B, (2.60 g, yield 68%). 1H NMR (500 MHz, CDCl3) δ ppm 7.82-7.93 (2H, m), 6.80-6.88 (2H, m), 5.44-5.56 (1H, m), 4.47 (2H, d, J=6.6 Hz), 3.80 (3H, s), 2.20-2.31 (4H, m), 1.50-1.71 (4H, m).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08030354B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_10 |
|---|
| ORD ID | ord-6bdae972316d4ef39d8fa7e3e551bd8d |
|---|
| 출처 메모 | uspto-grants-2011_10 |
|---|
