(3R)-3-(3-(((2-((1R)-2,2-Dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid → Methyl 2-(2,2-dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-carboxylate

HRID 1662512노트

반응식

HRID 1662512 반응식
CC1(C)CCC[C@@H:3]1[C:7]1C=C(COC2C=C([C@H](CC)CC(O)=O)C=CC=2)C=[CH:9][C:8]=1[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([O:34][CH3:35])[CH:29]=1.[CH3:37][C:38]1([CH3:72])[CH2:42][CH2:41][CH2:40][C@H:39]1C1C=C(COC2C=C([C@H](CC)CC(O)=O)C=CC=2)C=CC=1C1C=CC=C(OC)C=1.CC1(C)CCC[C@@H]1C1C=C(COC2C=C([C@@H:93](CC)[CH2:94][C:95]([OH:97])=[O:96])C=CC=2)C=CC=1C1C=CC=C(OC)C=1.[CH3:109]C1(C)CCC[C@H]1C1C=C(COC2C=C([C@@H](CC)CC(O)=O)C=CC=2)C=CC=1C1C=CC=C(OC)C=1>>[CH3:72][C:38]1([CH3:37])[CH2:39][CH2:40][CH2:41][CH:42]1[C:9]1[CH:93]=[C:94]([C:95]([O:97][CH3:109])=[O:96])[CH:3]=[CH:7][C:8]=1[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([O:34][CH3:35])[CH:29]=1

참가 물질

5

반응물 4

HCID 57705561(3R)-3-(3-(((2-((1R)-2,2-Dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acidHCID 57705814(3S)-3-(3-(((2-((1S)-2,2-dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acidHCID 57706391(3R)-3-(3-(((2-((1S)-2,2-dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acidHCID 57707128(3S)-3-(3-(((2-((1R)-2,2-dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid

생성물 1

HCID 57706985Methyl 2-(2,2-dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-carboxylate

실험 절차

(3R)-3-(3-(((2-((1S)-2,2-Dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid or (3R)-3-(3-(((2-((1R)-2,2-dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid or (3S)-3-(3-(((2-((1S)-2,2-dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid or (3S)-3-(3-(((2-((1R)-2,2-dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid (78.6). The title compound was prepared from chloromethyl compound 78.5F or 78.5G derived from 78.5D (peak one from the separation of the racemic alcohol) using the methods described herein. MS ESI (pos.) m/e: 504.2 (M+H2O)+, 509.2 (M+Na)+.

후처리

  1. customfrom the separation of the racemic alcohol)

출처 및 근거

ORD 기록
ord-efb0e4b76ddb4cad9bf2cbc3b197d21e
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030354B2

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