4-Bromoanisole → 3-hydroxy-3-(4-methoxyphenyl)-5-methyl-1,3-dihydro-2H-indol-2-one

HRID 1662687노트

반응식

HRID 1662687 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[CH3:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:20])[C:14]2=[O:21]>>[OH:21][C:14]1([C:2]2[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=2)[C:13]2[C:17](=[CH:18][CH:19]=[C:11]([CH3:10])[CH:12]=2)[NH:16][C:15]1=[O:20]

참가 물질

3

반응물 2

HCID 77304-BromoanisoleHCID 118405-Methylisatin

생성물 1

HCID 52977493-hydroxy-3-(4-methoxyphenyl)-5-methyl-1,3-dihydro-2H-indol-2-one수율 81.2%

실험 절차

With 5.61 g of 4-bromoanisole and 3.23 g of 5-methyl isatin as starting materials, 4.38 g of the title compound (light brown solid) was obtained by a similar method to Step 21-1.

출처 및 근거

ORD 기록
ord-c774a1eb56464d2d93bdb0bab694c0df
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030499B2

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