Boc-hyp-obzl → Benzyl (4R)-4-hydroxy-L-prolinate--hydrogen chloride (1/1)

HRID 1662723노트

반응식

HRID 1662723 반응식
[OH:1][C@H:2]1[CH2:6][N:5](C(OC(C)(C)C)=O)[C@H:4]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[CH2:3]1.[ClH:24].CCOC(C)=O>CCOC(C)=O>[ClH:24].[OH:1][C@H:2]1[CH2:6][NH:5][C@H:4]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[CH2:3]1

참가 물질

4

반응물 2

HCID 11902907Boc-hyp-obzlHCID 21866389Hydrogen chloride-ethyl acetate

생성물 1

HCID 16212860Benzyl (4R)-4-hydroxy-L-prolinate--hydrogen chloride (1/1)

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 10.0 g of the compound obtained in Step 157-1 in EtOAc (49 ml) was added a solution of 4 mol/L hydrochloric acid/EtOAc (39 ml). The solution was stirred at room temperature for one hour. The precipitated crystal was filtered, and the crystal was washed with EtOAc. The title compound in the amount of 6.70 g (colorless solid) was obtained.

후처리

  1. filtrationThe precipitated crystal was filtered
  2. washthe crystal was washed with EtOAc

출처 및 근거

ORD 기록
ord-2e21f97ab35b4a2a86719cd1c48cdde5
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030499B2

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