5-chloro-1H-indole-2,3-dione → 5-chloro-3-hydroxy-3-(2-methoxy-5-morpholin-4-ylphenyl)-1,3-dihydro-2H-indol-2-one

HRID 1662737

반응식

HRID 1662737 반응식
Br[C:2]1[CH:3]=[C:4]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[Cl:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][C:21](=[O:26])[C:20]2=[O:27]>>[Cl:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][C:21](=[O:26])[C:20]2([OH:27])[C:2]1[CH:3]=[C:4]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

참가 물질

3

반응물 2

HCID 872035-chloro-1H-indole-2,3-dioneHCID 674297914-(3-Bromo-4-methoxyphenyl)morpholine

생성물 1

HCID 674289095-chloro-3-hydroxy-3-(2-methoxy-5-morpholin-4-ylphenyl)-1,3-dihydro-2H-indol-2-one수율 77.3%

실험 절차

With 2.00 g of the compound obtained in Step 191-1 and 953 mg of 5-chloroisatin as starting materials, 1.52 g of the title compound (pale yellow amorphous) was obtained by a similar method to Step 21-1.

출처 및 근거

ORD 기록
ord-4295049017c74788805de3e2f81f0b14
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030499B2

연결된 노트

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