Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Amino-2-chlorobenzoic acid → 2-Chloro-5-(3-Fluoro-Benzoylamino)-Benzoic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Amino-2-chlorobenzoic acid | HCID 37879 | — |
| 반응물 | 3-Fluorobenzoyl chloride | HCID 74376 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Chloro-5-(3-Fluoro-Benzoylamino)-Benzoic Acid | HCID 28667504 | — |
반응 단계
5-Amino-2-chloro-benzoic acid (0.96 g, 5.58 mmol) was diluted with THF (60 mL), treated with 3-fluoro-benzoyl chloride (0.738 mL, 6.14 mmol) and stirred for 18 h. Solvents were then removed and resulting solids were triturated with DCM. After filtration, the title compound was obtained as a white solid (1.7 g, 99%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08030487B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-3a0aa06eb6a445f9bbbfcb5858b9c772 |
| 출처 메모 | uspto-grants-2011_10 |