Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Amino-2-chlorobenzoic acid → 2-Chloro-5-(Cyclohexanecarboxamido)Benzoic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Amino-2-chlorobenzoic acid | HCID 37879 | — |
| 반응물 | Cyclohexanecarbonyl chloride | HCID 75938 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Chloro-5-(Cyclohexanecarboxamido)Benzoic Acid | HCID 54920372 | 98.1% |
반응 단계
A solution of 5-amino-2-chlorobenzoic acid (0.34 g, 2.0 mmol) in THF (10 mL) was charged with cyclohexanecarbonyl chloride (0.27 mL, 1.7 mmol). The reaction was stirred for 16 h and then concentrated in vacuo. The residue was suspended in DCM and filtered to afford the title compounds as a white solid (0.47 g, 97%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08030487B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-c95b7900514f4738a107f2e40adbe181 |
| 출처 메모 | uspto-grants-2011_10 |