참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| 반응물 | 2,4-Oxazolidinedione | HCID 97389 | — |
| 반응물 | [1-(1-Isoquinolyl)-4-piperidyl]methanol | HCID 21096912 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-{[1-(1-Isoquinolyl)-4-piperidyl]methyl}-1,3-oxazolidine-2,4-dione | HCID 21096956 | — |
반응 단계
A solution of 2.01 g (9.95 mmol) of diisopropyl azodicarboxylate (DIAD) in 5 ml of tetrahydrofuran is added dropwise, under an inert atmosphere, to a solution of 2.4 g (9.95 mmol) of [1-(1-isoquinolyl)-4-piperidyl]methanol, prepared in step 5.1, 2.87 g (10.94 mmol) of triphenylphosphine and 1.21 g (11.93 mmol) of 1,3-oxazolidine-2,4-dione in 40 ml of tetrahydrofuran, cooled to about −10° C., the temperature of the reaction medium being maintained throughout between −10° C. and 0° C. Stirring is then continued at 0° C. for 1 hour and then at 25° C. for 18 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08034818B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_10 |
|---|
| ORD ID | ord-45f8cb3410c2441a9c511abfebd2011a |
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| 출처 메모 | uspto-grants-2011_10 |
|---|
