1'-Benzyl-5H-spiro[furo[3,4-b]pyridine-7,4'-piperidine] → 5H-Spiro[furo[3,4-b]pyridine-7,4'-piperidine]
반응식
C([N:8]1[CH2:13][CH2:12][C:11]2([C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[CH2:15][O:14]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[NH:8]1[CH2:9][CH2:10][C:11]2([C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[CH2:15][O:14]2)[CH2:12][CH2:13]1참가 물질
4
실험 절차
A solution of 0.39 g (1.4 mmol) 1′-benzyl-5H-spiro[furo[3,4-b]pyridine-7,4′-piperidine] in 14 ml ethanol was purged with argon prior to adding 0.15 g (10 mol %) palladium on activated charcoal. The flask was evacuated, refilled with hydrogen gas and stirred at room temperature under an atmosphere of hydrogen for 16 h. The catalyst was filtered off and washed with ethanol. The filtrate was concentrated to dryness to give the title compound (0.24 g, 91%) as an amorphous solid.
후처리
- customThe flask was evacuated
- additionrefilled with hydrogen gas
- filtrationThe catalyst was filtered off
- washwashed with ethanol
- concentrationThe filtrate was concentrated to dryness
출처 및 근거
- ORD 기록
- ord-ebcabceb1ccd42958554a98d213b2cfc
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08034937B2
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