3-Bromo-4-hydroxy-5-nitrobenzaldehyde → HCID 67435380, 화합물

HRID 1663385노트

반응식

HRID 1663385 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[C:9]=1[OH:10])[CH:5]=O.[CH3:14]/[C:15](/[NH2:19])=[CH:16]\[C:17]#[N:18].[CH2:20]([CH:23]1[CH2:28][C:27](=[O:29])[CH2:26][C:25](=O)[CH2:24]1)[CH2:21][CH3:22]>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]2[C:26]3[C:27](=[O:29])[CH2:28][CH:23]([CH2:20][CH2:21][CH3:22])[CH2:24][C:25]=3[NH:19][C:15]([CH3:14])=[C:16]2[C:17]#[N:18])[CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[C:9]=1[OH:10]

참가 물질

5

반응물 3

HCID 14943783-Bromo-4-hydroxy-5-nitrobenzaldehydeHCID 27372245-Propylcyclohexane-1,3-dioneHCID 53247203-Aminocrotonitrile

생성물 1

HCID 67435380HCID 67435380, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

A mixture of 3-bromo-4-hydroxy-5-nitro-benzaldehyde (18.26 g), 3-aminocrotonitrile (6.09 g) and 5-propylcyclohexane-1,3-dione (11.45 g) in ethanol (250 ml) was stirred at 80° C. for 17 h. The mixture was concentrated in vacuo. The residue was purified by chromatography on silicagel in dichloromethane as eluent.

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. customThe residue was purified by chromatography on silicagel in dichloromethane as eluent

출처 및 근거

ORD 기록
ord-5ded5b8bd1f84c27b4dbc561ba532673
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08034945B2

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