참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Phosphate, Dibasic | HCID 24203 | — |
| 반응물 | 6-Iodopyridazin-3-amine | HCID 10867834 | — |
| 반응물 | HCID 14221822 | HCID 14221822 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | Tert-butyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamate | HCID 46941915 | 63% |
반응 단계
To a solution of 3-amino-6-iodopyridazine (10.0 g, 45.2 mmol) in N,N-dimethylacetamide (100 mL) were added tert-butyl (chloroacetyl)carbamate (14.0 g, 72.4 mmol) and disodium hydrogenphosphate (16.1 g, 113 mmol), and the mixture was stirred at 120° C. for 3 hr. After cooling the mixture to room temperature, water (400 mL) was added to the mixture, and the precipitated crystals were filtrated, and washed with acetonitrile and petroleum ether to give the title compound (10.2 g, 63%) as a green powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08034812B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_10 |
|---|
| ORD ID | ord-a0e9ff83a97a417aa675e8332b54e6f3 |
|---|
| 출처 메모 | uspto-grants-2011_10 |
|---|
