Diethyl Ether → 6-Iodoimidazo[1,2-B]pyridazin-2-amine

HRID 1663619

반응식

HRID 1663619 반응식
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11]C(=O)OC(C)(C)C)[N:10]=2)[N:7]=1.Cl.C(OCC)(=O)C.C(OCC)C>C(OCC)(=O)C>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH2:11])[N:10]=2)[N:7]=1

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 21866389Hydrogen chloride-ethyl acetateHCID 46941915Tert-butyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamate

생성물 1

HCID 574410246-Iodoimidazo[1,2-B]pyridazin-2-amine수율 67%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a suspension of tert-butyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamate (10.2 g, 28.3 mmol) in ethyl acetate (50 mL) was added 4N hydrochloric acid/ethyl acetate (75 mL), and the mixture was stirred at room temperature for 4 hr. Diethyl ether (200 mL) was added to the reaction mixture, and the precipitate was filtrated. After washing with saturated aqueous sodium hydrogencarbonate solution, the filtrate was washed with water, acetonitrile and diethyl ether to give the title compound (4.9 g, 67%) as a green powder.

후처리

  1. filtrationthe precipitate was filtrated
  2. washAfter washing with saturated aqueous sodium hydrogencarbonate solution
  3. washthe filtrate was washed with water, acetonitrile and diethyl ether

출처 및 근거

ORD 기록
ord-1094202de2f14325bc375ca47f4dffeb
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08034812B2

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