Diethyl Ether → 6-Iodoimidazo[1,2-B]pyridazin-2-amine
반응식
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11]C(=O)OC(C)(C)C)[N:10]=2)[N:7]=1.Cl.C(OCC)(=O)C.C(OCC)C>C(OCC)(=O)C>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH2:11])[N:10]=2)[N:7]=1참가 물질
5
실험 절차
To a suspension of tert-butyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamate (10.2 g, 28.3 mmol) in ethyl acetate (50 mL) was added 4N hydrochloric acid/ethyl acetate (75 mL), and the mixture was stirred at room temperature for 4 hr. Diethyl ether (200 mL) was added to the reaction mixture, and the precipitate was filtrated. After washing with saturated aqueous sodium hydrogencarbonate solution, the filtrate was washed with water, acetonitrile and diethyl ether to give the title compound (4.9 g, 67%) as a green powder.
후처리
- filtrationthe precipitate was filtrated
- washAfter washing with saturated aqueous sodium hydrogencarbonate solution
- washthe filtrate was washed with water, acetonitrile and diethyl ether
출처 및 근거
- ORD 기록
- ord-1094202de2f14325bc375ca47f4dffeb
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08034812B2
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