Methoxyacetyl chloride → N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)-2-methoxyacetamide
반응식
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH2:11])[N:10]=2)[N:7]=1.[CH3:12][O:13][CH2:14][C:15](Cl)=[O:16]>CN(C)C(=O)C>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11][C:15](=[O:16])[CH2:14][O:13][CH3:12])[N:10]=2)[N:7]=1참가 물질
4
실험 절차
Using 6-iodoimidazo[1,2-b]pyridazin-2-amine (1.0 g, 3.85 mmol), N,N-dimethylacetamide (10 mL) and methoxyacetyl chloride (0.46 g, 4.23 mmol) as starting materials and in the same manner as in Reference Example 5, the title compound (1.01 g, 79%) was obtained as a dark brown powder.
출처 및 근거
- ORD 기록
- ord-3053563462d9454cb9caf0ae07da07dc
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08034812B2
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