Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,5-Dimethyl-2H-pyrazole-3-carbonyl chloride → 3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}-4-fluorophenyl methyl carbonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,5-Dimethyl-2H-pyrazole-3-carbonyl chloride | HCID 2736299 | — |
| 반응물 | 3-Amino-4-fluorophenyl methyl carbonate hydrochloride | HCID 57441031 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}-4-fluorophenyl methyl carbonate | HCID 57505433 | 87.2% |
반응 단계
Using a solution of 3-amino-4-fluorophenyl methyl carbonate hydrochloride (740 mg, 3.34 mmol) and 1,3-dimethyl-1H-pyrazole-5-carbonylchloride (556 mg, 3.51 mmol) in N,N-dimethylacetamide (10 mL), and by a reaction in the same manner as in Example 148, the title compound (895 mg, 87%) was obtained as a white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08034812B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-6630e95b25194dc8bb5852cbcbc69b09 |
| 출처 메모 | uspto-grants-2011_10 |