Potassium Carbonate → methyl 3-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylate

HRID 1663676노트

반응식

HRID 1663676 반응식
[OH:1][C:2]1[CH:6]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[N:4]([CH3:11])[N:3]=1.Br[CH2:13][CH2:14][O:15][CH3:16].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:16][O:15][CH2:14][CH2:13][O:1][C:2]1[CH:6]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[N:4]([CH3:11])[N:3]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl etherHCID 178498598HCID 178498598, 화합물

생성물 1

HCID 57441051methyl 3-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylate수율 94.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using methyl 3-hydroxy-1-methyl-1H-pyrazole-5-carboxylate (2.34 g, 15.0 mmol), 1-bromo-2-methoxyethane (3.13 g, 22.5 mmol), potassium carbonate (4.15 g, 30.0 mmol) and N,N-dimethylformamide (15 mL), and in the same manner as in Reference Example 57, the title compound (3.03 g, yield 94%) was obtained.

출처 및 근거

ORD 기록
ord-399c84d26d5b48ed9f07af3d92bcb111
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08034812B2

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