Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Adipic Dihydrazide → Amikacin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Adipic Dihydrazide | HCID 66117 | — |
| 반응물 | Amikacin Sulfate Salt | HCID 5458175 | — |
| 반응물 | (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol sulfate | HCID 86619106 | — |
| 반응물 | (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide sulfate | HCID 86619108 | — |
| 반응물 | tobramycin sulfate clindamycin HCl | HCID 131729235 | — |
| 생성물 | Amikacin | HCID 37768 | — |
반응 단계
Amikacin Sulfate (100 mg), DBM (200 mg), and 8 mg of adipic acid dihydrazide were placed into a beaker and mixed thoroughly. Oxidized dextran solution (Mw, 500,000; 66 mg/ml; 1 ml) was added to the mixture. Tobramycin-sulfate or tobramycin-sulfate/clindamycin-HCl (1/1) can be used in place of amikacin-sulfate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08039021B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-f1c377f4273646c9a4a40597dec3cc2f |
| 출처 메모 | uspto-grants-2011_10 |