2-fluoro-4-(1H-1,2,4-triazol-1-yl)benzonitrile → (2-Fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl)methanamine hydrochloride

HRID 1664139

반응식

HRID 1664139 반응식
[ClH:1].FC1C=CC(CN)=C(N2C=NC=N2)C=1.[F:16][C:17]1[CH:24]=[C:23]([N:25]2[CH:29]=[N:28][CH:27]=[N:26]2)[CH:22]=[CH:21][C:18]=1[C:19]#[N:20]>>[ClH:1].[F:16][C:17]1[CH:24]=[C:23]([N:25]2[CH:29]=[N:28][CH:27]=[N:26]2)[CH:22]=[CH:21][C:18]=1[CH2:19][NH2:20]

참가 물질

3

반응물 2

HCID 210698712-fluoro-4-(1H-1,2,4-triazol-1-yl)benzonitrileHCID 21069882(4-Fluoro-2-(1H-1,2,4-triazol-1-yl)phenyl)methanamine hydrochloride

생성물 1

HCID 21069834(2-Fluoro-4-(1H-1,2,4-triazol-1-yl)phenyl)methanamine hydrochloride수율 79%

실험 절차

This compound was prepared (79% yield) following the procedure for (4-fluoro-2-(1H-1,2,4-triazol-1-yl)phenyl)methanamine hydrochloride using (2-fluoro-4-(1H-1,2,4-triazol-1-yl)benzonitrile. 1H NMR (500 MHz, CD3OD) δ: 9.25 (1H, s), 8.46 (1H, s), 7.80 (1H, dd, J=8.6, 5.8 Hz), 7.64 (1H, dd, J=8.8, 2.4 Hz), 7.44 (1H, td, J=8.3, 2.6 Hz), 4.17 (2H, s). LCMS (M+H) calcd for C9H10N4F: 193.08; found: 193.16.

후처리

  1. customThis compound was prepared (79% yield)

출처 및 근거

ORD 기록
ord-12049a6b3d8b4c8684a71fd5b0deabba
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039458B2

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