Potassium Carbonate → HCID 67439609, 화합물

HRID 1664207

반응식

HRID 1664207 반응식
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[C:6]([C:13](Cl)=[O:14])[CH:5]=1.C([O-])([O-])=O.[K+].[K+].[CH3:23][O:24][CH:25]([O:28][CH3:29])[CH2:26][NH2:27]>C(Cl)Cl.C(OCC)(=O)C>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[C:6]([C:13]([NH:27][CH2:26][CH:25]([O:28][CH3:29])[O:24][CH3:23])=[O:14])[CH:5]=1

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 74774Methyl 3-(chlorocarbonyl)-5-nitrobenzoateHCID 89728Aminoacetaldehyde dimethyl acetal

생성물 1

HCID 67439609HCID 67439609, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매2회HCID 8857Ethyl Acetate용매

실험 절차

Under ice cooling a solution of 22.1 g (90.7 mmol) of 3-chlorocarbonyl-5-nitro-benzoic acid methyl ester (U.S. Pat. No. 4,120,891) in 200 ml of DCM is added dropwise to a stirred suspension of 11.2 g (181 mmol) of K2CO3 and 11.7 ml (109 mmol) of aminoacetaldehyde dimethylacetal in 200 ml of DCM. The mixture is stirred at ambient temperature for 2 days, diluted with ethyl acetate and extensively washed with water. The organic phase is dried over sodium sulfate and evaporated to yield the product in the form of a yellow oil.

후처리

  1. washextensively washed with water
  2. dry with materialThe organic phase is dried over sodium sulfate
  3. customevaporated
  4. customto yield the product in the form of a yellow oil

출처 및 근거

ORD 기록
ord-5168e8333bb54d3397d3ae3a4e195b8b
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039455B2

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