Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1664290생성일: 2026년 10월 26일
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid → 1-Cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
https://huagongshe.com/reaction/1664290
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid | HCID 7019465 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Hydrogen Bromide | HCID 260 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-Cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 11680737 | — |
반응 단계
A solution of 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (13.02 g) in HBr in AcOH (33%; 100 ml) was stirred at 100° C. for 1 day. The reaction mixture was cooled to 0° C. and diluted with water (400 ml). The resulting crystals were collected by filtration, affording, after drying, 12.4 g of a colourless material.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08039466B2 |
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| 출처 데이터셋 | uspto-grants-2011_10 |
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| ORD ID | ord-9bd35edf5e2f4e5b97b830c140e4376f |
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| 출처 메모 | uspto-grants-2011_10 |
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