Acetic Acid → 6-Amino-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
반응식
[CH2:1]([NH:6][C:7]([NH2:9])=[S:8])[CH2:2][CH2:3][CH2:4][CH3:5].[C:10]([CH2:12][C:13](OCC)=[O:14])#[N:11].[O-]CC.[Na+].C(O)(=O)C>C(O)C.O>[NH2:11][C:10]1[N:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[C:7](=[S:8])[NH:9][C:13](=[O:14])[CH:12]=1참가 물질
7
반응 조건
- 온도
- 75 °C
실험 절차
N-Pentylthiourea (10.0 g, 0.068 mol) was mixed with ethyl cyanoacetate (9.3 g, 0.082 mol) and sodium ethoxide (6.4 g, 0.094 mol) in ethanol (60 mL). The mixture was stirred at 75° C. overnight. After cooling, a solution of 10% acetic acid in water (150 mL) was added. The solid formed was collected by filtration and washed with water to afford the desired product (9.5 g, 65% yield). LCMS calculated for C9H16N3OS: (M+H) 214.1. found 214.1.
후처리
- temperatureAfter cooling
- customThe solid formed
- filtrationwas collected by filtration
- washwashed with water
출처 및 근거
- ORD 기록
- ord-62f686ba8d4a412b84922973a045f5d7
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08039478B2
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