Water → (2,5-Dimethoxyphenyl)-2-oxoacetaldehyde
반응식
[Se](=O)=O.[OH2:4].[CH3:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:8]=1[C:15](=[O:17])[CH3:16]>O1CCOCC1>[CH3:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:8]=1[C:15](=[O:17])[CH:16]=[O:4]참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
A mixture of 3.66 g (33 mmol) of selenium dioxide, 1 ml of water and 25 ml of dioxane is heated to 60° C. 5.4 g (30 mmol) of 2′,5′-dimethoxyacetophenone are added and the mixture is refluxed for 16 hours. The solvents are evaporated off (orange-coloured oil; 6 g) and the product obtained is purified by flash chromatography (dichloromethane) (3.1 g of yellow oil; 53%).
후처리
- temperaturethe mixture is refluxed for 16 hours
- customThe solvents are evaporated off (orange-coloured oil; 6 g)
- customthe product obtained
- customis purified by flash chromatography (dichloromethane) (3.1 g of yellow oil; 53%)
출처 및 근거
- ORD 기록
- ord-0470c3e2d8ff4445b1914697fcfa1232
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07737176B2
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