Water → (2,5-Dimethoxyphenyl)-2-oxoacetaldehyde

HRID 16646

반응식

HRID 16646 반응식
[Se](=O)=O.[OH2:4].[CH3:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:8]=1[C:15](=[O:17])[CH3:16]>O1CCOCC1>[CH3:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:8]=1[C:15](=[O:17])[CH:16]=[O:4]

참가 물질

5

반응물 3

HCID 962WaterHCID 24007Selenium DioxideHCID 709912',5'-Dimethoxyacetophenone

생성물 1

HCID 81761435(2,5-Dimethoxyphenyl)-2-oxoacetaldehyde

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
60 °C

실험 절차

A mixture of 3.66 g (33 mmol) of selenium dioxide, 1 ml of water and 25 ml of dioxane is heated to 60° C. 5.4 g (30 mmol) of 2′,5′-dimethoxyacetophenone are added and the mixture is refluxed for 16 hours. The solvents are evaporated off (orange-coloured oil; 6 g) and the product obtained is purified by flash chromatography (dichloromethane) (3.1 g of yellow oil; 53%).

후처리

  1. temperaturethe mixture is refluxed for 16 hours
  2. customThe solvents are evaporated off (orange-coloured oil; 6 g)
  3. customthe product obtained
  4. customis purified by flash chromatography (dichloromethane) (3.1 g of yellow oil; 53%)

출처 및 근거

ORD 기록
ord-0470c3e2d8ff4445b1914697fcfa1232
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737176B2

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