Sodium Sulfite → HCID 67440013, 화합물

HRID 1664785노트

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HRID 1664785 반응식
[CH3:1][O:2][C:3]([CH:5]([CH:15]1[CH2:20][CH2:19][N:18]([C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])[CH2:17][CH2:16]1)[CH2:6][C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=C)=[O:4].I([O-])(=O)(=O)=[O:32].[Na+].S([O-])([O-])=O.[Na+].[Na+].C(=O)(O)[O-].[Na+]>O1CCCC1.O.[Os](=O)(=O)(=O)=O>[CH3:1][O:2][C:3]([CH:5]([CH:15]1[CH2:16][CH2:17][N:18]([C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])[CH2:19][CH2:20]1)[CH2:6][C:7](=[O:32])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:4]

참가 물질

8

반응물 4

HCID 24437Sodium SulfiteHCID 516892Sodium BicarbonateHCID 23667635Sodium periodateHCID 67440613HCID 67440613, 화합물

생성물 1

HCID 67440013HCID 67440013, 화합물

시약·촉매·용매 3

HCID 30318Osmium Tetroxide촉매HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

Osmium tetroxide (2.5 wt. % in t-BuOH; 0.2 mL, 0.001 mmol) was added to a solution of benzyl 4-[1-(methoxycarbonyl)-3-phenylbut-3-en-1-yl]piperidine-1-carboxylate (2.11 g, 5.19 mmol) in tetrahydrofuran (20 mL). Sodium periodate (3.33 g, 15.6 mmol) in water (17 mL) was added to the reaction mixture. After 18 h, saturated aqueous sodium sulfite and saturated aqueous sodium bicarbonate were added and the mixture was extracted with ethyl acetate (4×). The combined organic extracts were dried over magnesium sulfate, filtered and concentrated to give the title compound. MS 410.1 (M+1).

후처리

  1. extractionthe mixture was extracted with ethyl acetate (4×)
  2. dry with materialThe combined organic extracts were dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5dd042ebae244b6b8e3722763f53f9fd
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039460B2

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