Acetyl chloride → HCID 178471808, 화합물

HRID 1664987노트

반응식

HRID 1664987 반응식
Cl.[CH2:2]([O:4][C:5](=[O:14])[CH2:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([NH2:13])[CH2:9][CH2:8]1)[CH3:3].CCN(CC)CC.[C:22](Cl)([CH3:24])=[O:23]>C(Cl)Cl>[CH2:2]([O:4][C:5](=[O:14])[CH2:6][C@H:7]1[CH2:8][CH2:9][C@H:10]([NH:13][C:22](=[O:23])[CH3:24])[CH2:11][CH2:12]1)[CH3:3]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 178471807HCID 178471807, 화합물2회

생성물 1

HCID 178471808HCID 178471808, 화합물수율 82.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(trans-4-Amino-cyclohexyl)-acetic acid ethyl ester hydrochloride (10.0 g, 45 mmol, intermediate B) was dissolved in CH2Cl2 (150 ml) and Et3N and AcCl (3.89 g, 50 mmol) were added. The reaction mixture was stirred 3 h at room temperature before washing it with H2O and brine. After drying (Na2SO4) the solvent was evaporated to yield 8.42 g (82%, 37 mmol) of a white solid. MS (m/z): 228.3 ([M+H]+).

후처리

  1. washbefore washing it with H2O and brine
  2. dry with materialAfter drying (Na2SO4) the solvent
  3. customwas evaporated

출처 및 근거

ORD 기록
ord-dcc0237461bb47f4b3b2fe28754988b0
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039490B2

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