Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chlorobenzenesulfonyl chloride → N-(2-bromo-thiazol-5-ylmethyl)-2-chloro-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chlorobenzenesulfonyl chloride | HCID 76187 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | c-(2-Bromo-thiazol-5-yl)-methylamine hydrochloride | HCID 71434973 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(2-bromo-thiazol-5-ylmethyl)-2-chloro-benzenesulfonamide | HCID 67441135 | — |
반응 단계
In analogy to example 1, step 1, 2-bromo-5-aminomethyl-thiazole hydrochloride was reacted with 2-chlorobenzenesulfonylchloride and N,N-diisopropyl ethyl amine in dichloromethane to give N-(2-bromo-thiazol-5-ylmethyl)-2-chloro-benzenesulfonamide as an off-white solid. MS: 367.0 ([M+H]+)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08039493B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-7059e3810b764eb084d30660e5b914c0 |
| 출처 메모 | uspto-grants-2011_10 |