Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chlorobenzenesulfonyl chloride → N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chlorobenzenesulfonyl chloride | HCID 76187 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | [(4-Bromothiophen-2-yl)methyl](2-methylpropyl)amine | HCID 28833175 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide | HCID 67439155 | — |
반응 단계
In analogy to example 13, step 2, (4-bromo-thiophen-2-ylmethyl)-isobutyl-amine was reacted with 2-chlorobenzenesulfonylchloride in presence of N,N-diisopropyl ethyl amine in dichloromethane to give N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08039493B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-08e901e300cb46c0a20f0af16c99040d |
| 출처 메모 | uspto-grants-2011_10 |