Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 2-chloro-N-isobutyl-N-[4-(5-methanesulfonyl-pyridin-3-yl)-thiophen-2-ylmethyl]-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 5-(Methylsulphonyl)pyridine-3-boronic acid | HCID 44119381 | — |
| 반응물 | N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide | HCID 67439155 | — |
| 촉매 | HCID 178418807 | HCID 178418807 | — |
| 용매 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 생성물 | 2-chloro-N-isobutyl-N-[4-(5-methanesulfonyl-pyridin-3-yl)-thiophen-2-ylmethyl]-benzenesulfonamide | HCID 25234322 | — |
반응 단계
In analogy to example 1, step 3, N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide (example 14, step 2) was reacted with 5-(methylsulfonyl)-3-pyridineboronic acid, Na2CO3 and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct in dioxane/water to give 2-chloro-N-isobutyl-N-[4-(5-methanesulfonyl-pyridin-3-yl)-thiophen-2-ylmethyl]-benzenesulfonamide as an off-white solid. MS: 557.1 ([M+OAc]−)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08039493B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-84ec80d3f4534219b5e84c573fb4ac37 |
| 출처 메모 | uspto-grants-2011_10 |