Benzoic acid, 2-(methylamino)-3-nitro-, methyl ester → Benzoic acid, 3-amino-2-(methylamino)-, methyl ester

HRID 1665221

반응식

HRID 1665221 반응식
[CH3:1][NH:2][C:3]1[C:12]([N+:13]([O-])=O)=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6]>O1CCCC1.[Pd]>[NH2:13][C:12]1[C:3]([NH:2][CH3:1])=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6]

참가 물질

4

반응물 1

HCID 59635415Benzoic acid, 2-(methylamino)-3-nitro-, methyl ester

생성물 1

HCID 59202087Benzoic acid, 3-amino-2-(methylamino)-, methyl ester수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a suspension of methyl 2-(methylamino)-3-nitrobenzoate (2.10 g, 10.0 mmol) in tetrahydrofuran (40 mL) was added palladium on carbon (210 mg), and the mixture was purged with hydrogen and stirred under balloon pressure hydrogen for 2 hr at room temperature. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound (1.80 g, 10.0 mmol, 100%) as a pale yellow oil.

후처리

  1. customthe mixture was purged with hydrogen
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-12a9ff79db85438388d53b49bc1aff21
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039500B2

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