1,5-Dimethyl-1H-Pyrazole-3-Carbonyl Chloride → 1'-[(1,5-dimethyl-1H-pyrazol-3-yl)carbonyl]spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione
반응식
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.[CH3:22][N:23]1[C:27]([CH3:28])=[CH:26][C:25]([C:29](Cl)=[O:30])=[N:24]1>>[CH3:22][N:23]1[C:27]([CH3:28])=[CH:26][C:25]([C:29]([N:1]2[CH2:2][CH2:3][C:4]3([O:11][C:10]4[C:12]5[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=4[S:8][CH2:7]3)=[CH:16][CH:15]=[CH:14][CH:13]=5)[CH2:5][CH2:6]2)=[O:30])=[N:24]1참가 물질
3
실험 절차
Compound 45 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 1,5-dimethyl-1H-pyrazole-3-carbonyl chloride and conditions outlined in procedure N. M.p.=184-185° C.; 300 MHz 1H NMR (DMSO-d6) δ 8.04 (d, 1H), 7.80 (m, 1H), 7.65 (m, 1H), 7.46 (m, 1H), 6.42 (s, 1H), 3.80 (s, 3H), 3.47 (m, 2H), 2.98 (s, 2H), 2.26 (s, 3H), 2.18 (m, 2H), 1.90 (m 2H), 1.62 (brs, 2H); LCMS: 424 [M+H].
출처 및 근거
- ORD 기록
- ord-b4f38874e55749c7bc84dfbe369e7a7c