6-Chloroimidazo(2,1-b)(1,3)thiazole-5-sulfonyl chloride → 1'-[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonyl]spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

HRID 1665309

반응식

HRID 1665309 반응식
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.[Cl:22][C:23]1[N:24]=[C:25]2[N:29]([C:30]=1[S:31](Cl)(=[O:33])=[O:32])[CH:28]=[CH:27][S:26]2>>[Cl:22][C:23]1[N:24]=[C:25]2[N:29]([C:30]=1[S:31]([N:1]1[CH2:2][CH2:3][C:4]3([O:11][C:10]4[C:12]5[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=4[S:8][CH2:7]3)=[CH:16][CH:15]=[CH:14][CH:13]=5)[CH2:5][CH2:6]1)(=[O:33])=[O:32])[CH:28]=[CH:27][S:26]2

참가 물질

3

반응물 2

HCID 27997176-Chloroimidazo(2,1-b)(1,3)thiazole-5-sulfonyl chlorideHCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

생성물 1

HCID 576618301'-[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonyl]spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

실험 절차

Compound 77 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl chloride and conditions outlined in procedure P. M.p.=265-267° C.; 400 MHz 1H NMR (DMSO-d6) δ: 8.08-8.05 (m, 1H), 7.87-7.84 (m, 1H), 7.61-7.50 (m, 3H), 7.33-7.29 (m, 1H), 3.66-3.60 (m, 2H), 3.11 (s, 2H), 3.02-2.95 (m, 2H), 2.12-2.06 (m, 2H), 1.95-1.84 (m, 2H); LCMS: 522 [M+H].

출처 및 근거

ORD 기록
ord-cf85769b0ddf479b92772d8f2ae2267c
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039503B2

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