Triethylamine → [4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(1-hydroxyethyl)phenyl]urea

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	4-Amino-alpha-methylbenzenemethanol	HCID 85753	—
반응물	Triphosgene	HCID 94429	—
반응물	4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline	HCID 45379087	—
용매	Dichloromethane	HCID 6344	—
생성물	[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(1-hydroxyethyl)phenyl]urea	HCID 44515378	24%

반응 조건

온도	0 °C

반응 단계

To a stirred mixture of 4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline (0.140, 0.40 mmoles) in methylene chloride at 0° C. was added triphosgene (0.25, 0.84 mmoles) and Et3N (3 mL). The reaction mixture was stirred for 20 minutes at 0° C. Then 1-(4-aminophenyl)ethanol (0.10 g, 0.73 mmoles) was added to the mixture. The reaction mixture was stirred for about 16 hours at room temperature. The solvent was removed. The residue was dissolved in DMSO and place at HPLC using acetonitrile buffer TFA to give 48 mg (24%) of [4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(1-hydroxyethyl)phenyl]urea. M+H 506.4.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08039469B2
출처 데이터셋	uspto-grants-2011_10
ORD ID	ord-d83666c028ec450d98bf9424e6ec8d7f
출처 메모	uspto-grants-2011_10