Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 16656생성일: 2026년 10월 24일
1-Hydroxybenzotriazole → Tert-butyl 2-[3-{1-(4-sulfamoylphenyl)-5-p-tolyl-1h-pyrazol-3-yl}propanamido]ethylcarbamate
https://huagongshe.com/ko/reaction/16656
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | N-BOC-ethylenediamine | HCID 187201 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | Celecox Sulforhodamine | HCID 131728181 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Tert-butyl 2-[3-{1-(4-sulfamoylphenyl)-5-p-tolyl-1h-pyrazol-3-yl}propanamido]ethylcarbamate | HCID 66813400 | 46% |
반응 단계
a Celecox-Sulforhodamine Analog: Compound 30f was synthesized by the method outlined in FIG. 3. Briefly, Compound 30c as synthesized as set forth hereinabove. Compound 30c was then complexed with tert-butyl 2-aminoethylcarbamate for 16 hours at room temperature in the presence of 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride (EDCl), 1-hydroxybenzotriazole (HOBt), and N,N-diisopropylethylamine (DIPEA) in mimethylformamide (DMF) to produce tert-butyl 2-[3-{1-(4-sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl}propanamido]ethylcarbamate as a yellow solid (46% yield). This product was then dissolved in dichloromethane and treated with HCl (gas) for 2 hours at room temperature, producing N-(2-aminoethyl)-3-{1-(4-sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl}propanamide hydrochloride as a yellow solid (80% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07736624B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-de5eb08e7d1e4c42908d8980e52fde1c |
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| 출처 메모 | uspto-grants-2010_06 |
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