Diethyl methylmalonate → 3-Methoxy-2-methyl-3-oxopropanoic acid

HRID 1665674

반응식

HRID 1665674 반응식
[OH-].[K+].[CH2:3]([O:5][C:6](=[O:14])[CH:7]([CH3:13])[C:8]([O:10]CC)=[O:9])C>CO>[CH3:3][O:5][C:6](=[O:14])[CH:7]([CH3:13])[C:8]([OH:10])=[O:9]

참가 물질

4

반응물 2

HCID 11857Diethyl methylmalonateHCID 14797Potassium Hydroxide

생성물 1

HCID 3006933-Methoxy-2-methyl-3-oxopropanoic acid수율 47.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

KOH (386 mg, 6.88 mmol) was added to a solution 2-methyl-malonic acid diethyl ester (1 g, 5.74 mmol) in methanol (7 mL). The resulting mixture was stirred overnight at ambient temperature then concentrated. The resulting residue was diluted with water, acidified with conc. HCl and the product was extracted with dichloromethane. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford 360 mg (47%) of 2-methyl-malonic acid monomethyl ester

후처리

  1. concentrationthen concentrated
  2. additionThe resulting residue was diluted with water
  3. extractionthe product was extracted with dichloromethane
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ffa459bab6874c01a1a05d203d9280f9
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08039463B2

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