Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Aminobiphenyl → N-biphenyl-4-yl-2-Methyl-malonamic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Aminobiphenyl | HCID 7102 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 3-Methoxy-2-methyl-3-oxopropanoic acid | HCID 300693 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-biphenyl-4-yl-2-Methyl-malonamic acid methyl ester | HCID 57875815 | 77.7% |
반응 단계
HOBt (245 mg, 1.8 mmol), DMAP (370 mg, 3.0 mmol), EDCI.HCl (348 mg, 1.8 mmol) followed by biphenyl-4-ylamine (307 mg, 1.8 mmol) were added to a stirred solution of 2-methyl-malonic acid monomethyl ester (200 mg, 1.5 mmol) in DMF (3 mL) and the resulting mixture was stirred at ambient temperature overnight. The reaction mixture was then diluted with water and the product was extracted with ethyl acetate. The ethyl acetate layer was washed with brine solution and concentrated under reduced pressure to afford 330 mg (77%) of N-biphenyl-4-yl-2-Methyl-malonamic acid methyl ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08039463B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-455ba1db926f4928b12bd1c295bb1b98 |
| 출처 메모 | uspto-grants-2011_10 |