Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1666200생성일: 2026년 10월 27일
Potassium Carbonate → 2-Butoxy-7,8-dihydro-9-(3-[4-(4-methylbenzyl)piperazin-1-yl]propyl)-8-oxoadenine
https://huagongshe.com/reaction/1666200
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(4-Methylbenzyl)piperazine | HCID 764723 | — |
| 반응물 | 2-Butoxy-9-(3-bromopropyl)-7,8-dihydro-8-oxoadenine | HCID 59288031 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Butoxy-7,8-dihydro-9-(3-[4-(4-methylbenzyl)piperazin-1-yl]propyl)-8-oxoadenine | HCID 25014764 | 20.2% |
반응 단계
The compound (180 mg) obtained in Step (ii), potassium carbonate (140 mg) and 4-methylbenzylpiperazine (130 mg) were added to DMF (5 mL), and the mixture was stirred at 70° C. for 3 hours. The insoluble materials were collected by filtration, and the residue was purified by silica gel column chromatography (CHCl3:MeOH:28% NH3 aq.=100:3:2) to give the title compound (48 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08044056B2 |
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| 출처 데이터셋 | uspto-grants-2011_10 |
|---|
| ORD ID | ord-b86f59bebe9f499f8c4dc1a19f62f9de |
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| 출처 메모 | uspto-grants-2011_10 |
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