Acetyl chloride → alpha-Acetoxy-3,4,5-trimethoxyphenyl-acetic acid

HRID 1666297노트

반응식

HRID 1666297 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[CH:6]([OH:10])[C:7]([OH:9])=[O:8].[C:18](Cl)(=[O:20])[CH3:19]>>[C:18]([O:10][CH:6]([C:5]1[CH:11]=[C:12]([O:16][CH3:17])[C:13]([O:14][CH3:15])=[C:3]([O:2][CH3:1])[CH:4]=1)[C:7]([OH:9])=[O:8])(=[O:20])[CH3:19]

참가 물질

3

반응물 2

HCID 6367Acetyl chlorideHCID 139030963,4,5-Trimethoxymandelic acid

생성물 1

HCID 67081678alpha-Acetoxy-3,4,5-trimethoxyphenyl-acetic acid

실험 절차

3,4,5-Trimethoxymandelic acid (80.5 g) was treated with acetyl chloride (150 ml) at room temperature for three hours. The clear solution was concentrated to dryness under vacuum, and the oily residue was crystallized from toluene (280 ml) giving pure α-acetoxy-3,4,5-trimethoxyphenylacetic acid (80.9 g), m.p. 135-139° C.

후처리

  1. concentrationThe clear solution was concentrated to dryness under vacuum
  2. customthe oily residue was crystallized from toluene (280 ml)

출처 및 근거

ORD 기록
ord-a59961e20d414f499f2b7ec6ebbb983a
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044067B2

반응 노트

불러오는 중…