Methanol → N-(3-methoxybenzyl)-N-methyl-2-(3,5-dimetoxyphenyl)-2-(phenylsulfinyl)acetamide

HRID 1666309

반응식

HRID 1666309 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]([CH3:28])[C:8](=[O:27])[CH:9]([C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[C:19]([O:25][CH3:26])[CH:18]=1)[S:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.I([O-])(=O)(=O)=[O:33].[Na+].CO>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]([CH3:28])[C:8](=[O:27])[CH:9]([C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[C:19]([O:25][CH3:26])[CH:18]=1)[S:10]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:33]

참가 물질

5

반응물 3

HCID 887MethanolHCID 23667635Sodium periodateHCID 67081986N-(3-methoxy-benzyl)-N-methyl-2-(3,5-dimetoxyphenyl)-2-(phenylsulfanyl)-acetamide

생성물 1

HCID 67081824N-(3-methoxybenzyl)-N-methyl-2-(3,5-dimetoxyphenyl)-2-(phenylsulfinyl)acetamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of the acetamide derivative from step 3 above (4.1 g), sodium metaperiodate (3.3 g), methanol (50 ml) and water (30 ml) was heated under reflux for 1.5 hours. The reaction mixture was filtered and the filtrate concentrated to dryness. The residue was purified by chromatography on silica gel using ethyl acetate as eluent, giving N-(3-methoxybenzyl)-N-methyl-2-(3,5-dimetoxyphenyl)-2-(phenylsulfinyl)acetamide (2.7 g) as a viscous oil.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 1.5 hours
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate concentrated to dryness
  5. customThe residue was purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-ddf91edd5dd64618ac40df3249b9348b
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044067B2

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