Pyridine → Phenyl (6-methoxypyrazin-2-yl)carbamate
반응식
[NH2:1][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH3:9])[N:3]=1.CC#N.N1C=CC=CC=1.[C:19]1([O:25][C:26](Cl)=[O:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C1COCC1>[CH3:9][O:8][C:4]1[N:3]=[C:2]([NH:1][C:26](=[O:27])[O:25][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:7]=[N:6][CH:5]=1참가 물질
6
실험 절차
2-Amino-6-methoxy-pyrazine (1.00 g, 8 mmol) was dissolved in a mix of 1:2 THF:MeCN (30 mL), cooled to 0° C., and treated with pyridine (0.664 g, 8.3 mmol) followed by the dropwise addition of phenylchloroformate (1.3 g, 8.3 mmol) in THF (10 mL). After stirring for 18 h, the resulting white solid was collected by filtration (1.3 g, 68%) and was used without further purification.
후처리
- filtrationthe resulting white solid was collected by filtration (1.3 g, 68%)
- customwas used without further purification
출처 및 근거
- ORD 기록
- ord-b1d53a37aed0422eaba5b63a3da91fa7
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08044052B2
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