Pyridine → Phenyl 3-methylpyrazin-2-ylcarbamate

HRID 1666359

반응식

HRID 1666359 반응식
[NH2:1][C:2]1[C:7]([CH3:8])=[N:6][CH:5]=[CH:4][N:3]=1.CC#N.N1C=CC=CC=1.[C:18]1([O:24][C:25](Cl)=[O:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1COCC1>[CH3:8][C:7]1[C:2]([NH:1][C:25](=[O:26])[O:24][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:3][CH:4]=[CH:5][N:6]=1

참가 물질

6

반응물 4

HCID 1049PyridineHCID 6342AcetonitrileHCID 15891Phenyl chloroformateHCID 3022842-Amino-3-methylpyrazine

생성물 1

HCID 66875712Phenyl 3-methylpyrazin-2-ylcarbamate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 2-amino-3-methyl-pyrazine (1.50 g, 1.37 mmol) in a mix of 1:2 THF:MeCN (30 mL), and pyridine (0.664 g, 1.44 mmol) was treated dropwise with phenylchloroformate (1.3 g, 1.44 mmol) in THF (10 mL). After stirring for 18 h, the reaction mixture was concentrated in vacuo to a solid and was used without further purification.

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo to a solid
  2. customwas used without further purification

출처 및 근거

ORD 기록
ord-d151172da7374fd68c235531ce430bd0
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044052B2

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