Thionyl Chloride → 2,4-Difluoro-3-methoxybenzoyl chloride
반응식
[F:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([F:13])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:16])=O>C(OCC)(=O)C>[F:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([F:13])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:16])=[O:5]참가 물질
4
실험 절차
A mixture of 2,4-difluoro-3-methoxybenzoic acid (2.1 g, 11.1 mmol), thionyl chloride (5 mL), and ethyl acetate (30 mL) is refluxed for 4 h. All volatiles are removed in vacuo, and the remaining residue is used directly in the next synthetic step.
후처리
- temperatureis refluxed for 4 h
- customAll volatiles are removed in vacuo
출처 및 근거
- ORD 기록
- ord-fa2eee3b14c54461ab380684b254c85f
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08044204B2
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