Trifluoroacetic acid → 3,3-Bis(4-fluorophenyl)-1-(2-(piperazin-1-yl)ethyl)pyrrolidin-2-one

HRID 1667131노트

반응식

HRID 1667131 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][N:15]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)[C:9]2=[O:28])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O.C(N(CC)CC)C>ClCCl>[F:35][C:32]1[CH:33]=[CH:34][C:29]([C:8]2([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:9]2=[O:28])=[CH:30][CH:31]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 67359885Tert-butyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)ethyl)piperazine-1-carboxylate

생성물 1

HCID 674430113,3-Bis(4-fluorophenyl)-1-(2-(piperazin-1-yl)ethyl)pyrrolidin-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The product from Example 63B (2.00 g, 4.12 mmol) was dissolved in dichloromethane (40 mL) and treated with trifluoroacetic acid (7.40 g, 64.9 mmol) at 0° C. The reaction was allowed to come to room temperature and stirred for 1 hour. The reaction was neutralized with triethylamine and concentrated. The residue was taken into ethyl acetate, and then it was washed with water and brine, dried with MgSO4, filtered and concentrated to give the title compound. MS (DCI) m/z 386.2 (M+H)+.

후처리

  1. customto come to room temperature
  2. concentrationconcentrated
  3. washit was washed with water and brine
  4. dry with materialdried with MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-008ab5481fc1483db7a204bdbd047ecb
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044069B2

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