Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanolamine → 1-(2-Hydroxyethyl)-3,3-diphenylpyrrolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanolamine | HCID 700 | — |
| 반응물 | Dihydro-3,3-diphenyl-2(3H)-furanone | HCID 70393 | — |
| 촉매 | Zincchloride | HCID 3007855 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(2-Hydroxyethyl)-3,3-diphenylpyrrolidin-2-one | HCID 67357537 | — |
반응 단계
3,3-Diphenyldihydrofuran-2(3H)-one (1.0 g, 4.20 mmol), 2-aminoethanol (2.56 g, 42.0 mmol) and zinc chloride (0.020 g, 0.147 mmol) were heated together at 100° C. for 18 hours. The reaction was cooled, diluted with ethyl acetate, washed with water and brine, dried with MgSO4, filtered and concentrated. Silica gel chromatography eluting with 5% methanol/dichloromethane gave the title compound. MS (DCI+) m/z 282.2 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08044069B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-ac40d96196be48c5bf8ca651dad70490 |
| 출처 메모 | uspto-grants-2011_10 |