Trifluoroacetic acid → 1-(2-(4-Aminopiperidin-1-yl)-2-oxoethyl)-3,3-diphenylpiperidin-2-one

HRID 1667164노트

반응식

HRID 1667164 반응식
[O:1]=[C:2]1[C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][N:3]1[CH2:20][C:21]([N:23]1[CH2:28][CH2:27][CH:26]([NH:29]C(=O)OC(C)(C)C)[CH2:25][CH2:24]1)=[O:22].FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:29][CH:26]1[CH2:27][CH2:28][N:23]([C:21](=[O:22])[CH2:20][N:3]2[CH2:4][CH2:5][CH2:6][C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:2]2=[O:1])[CH2:24][CH2:25]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67443748HCID 67443748, 화합물

생성물 1

HCID 673590361-(2-(4-Aminopiperidin-1-yl)-2-oxoethyl)-3,3-diphenylpiperidin-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The product from Example 87A was dissolved in methylene chloride (5 mL) and treated with trifluoroacetic acid (2 mL) at room temperature for 1 hour. Then the reaction mixture was concentrated, partitioned between methylene chloride and an aqueous solution of sodium bicarbonate. The organic layer was separated, dried over magnesium sulfate, and concentrated to yield the title compound. MS (ESI+) m/z 391 (M+H)+.

후처리

  1. concentrationThen the reaction mixture was concentrated
  2. custompartitioned between methylene chloride
  3. customThe organic layer was separated
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ec506fc63b2b446b89268750f02f3281
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044069B2

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