2-Amino-5-(trifluoromethyl)pyridine → 2-[3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl]-N-(5-cyanopyridin-2-yl)acetamide

참여 물질

역할	이름	HCID	투입량
반응물	2-Amino-5-(trifluoromethyl)pyridine	HCID 735862	—
반응물	2-Amino-5-cyanopyridine	HCID 818260	—
반응물	2-(3,3-Bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid	HCID 67357191	—
반응물	2-(2-Oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid	HCID 67359013	—
생성물	2-[3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl]-N-(5-cyanopyridin-2-yl)acetamide	HCID 67446520	—

반응 단계

The title compound was prepared using the procedure described in Example 246 substituting 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetic acid from Example 58D for 2-(2-oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid and 6-aminonicotinonitrile for 5-(trifluoromethyl)pyridin-2-amine. 1H NMR (300 MHz, CDCl3) δ ppm 8.55 (s, 2H), 8.25 (d, J=8.7, 1H), 7.93 (dd, J=2.1, 8.7, 1H), 7.43-7.22 (m, 4H), 7.07-6.98 (m, 4H), 4.21 (s, 2H), 3.55 (t, J=6.5, 2H), 2.83 (t, J=6.5, 2H); MS (DCI) m/z 433.0 (M+H)+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08044069B2
출처 데이터셋	uspto-grants-2011_10
ORD ID	ord-d01a9d3dccf0496184c5dc39a3c01f87
출처 메모	uspto-grants-2011_10