Ethanol → Ethyl (4-(trifluoromethyl)phenyl)acetate

HRID 1667290노트

반응식

HRID 1667290 반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.S(=O)(=O)(O)O.[CH2:20](O)[CH3:21]>>[F:1][C:2]([F:13])([F:14])[C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]([O:12][CH2:20][CH3:21])=[O:11])=[CH:7][CH:8]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 118342(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid

생성물 1

HCID 14134124Ethyl (4-(trifluoromethyl)phenyl)acetate

실험 절차

2-(4-(Trifluoromethyl)phenyl)acetic acid (5.0 g, 24.49 mmol) was dissolved in ethanol (100 mL). Concentrated sulfuric acid (1 mL) was added, and the mixture was refluxed overnight. After cooling to room temperature, the reaction mixture was concentrated and diluted with diethyl ether. The organic solvent solution was then extracted with water, saturated aqueous sodium bicarbonate solution, and brine. The organic layer was then dried with magnesium sulfate, filtered, and concentrated to obtain the title compound. MS (DCI+) m/z 250 (M+NH4)+.

후처리

  1. temperaturethe mixture was refluxed overnight
  2. concentrationthe reaction mixture was concentrated
  3. additiondiluted with diethyl ether
  4. extractionThe organic solvent solution was then extracted with water, saturated aqueous sodium bicarbonate solution, and brine
  5. dry with materialThe organic layer was then dried with magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d8a5426e37f94f3a94ce5707c4fc0e4f
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044069B2

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