Sulfuric Acid → Methyl 2,5-dibromo-4-methylbenzoate

HRID 1667328노트

반응식

HRID 1667328 반응식
[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[C:18](OCC)(=O)C>CO>[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:8]([Br:12])=[CH:7][C:3]=1[C:4]([O:6][CH3:18])=[O:5]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 8857Ethyl AcetateHCID 232948852,5-Dibromo-4-methylbenzoic acid

생성물 1

HCID 26338328Methyl 2,5-dibromo-4-methylbenzoate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2,5-dibromo-4-methylbenzoic acid 5.88 g, 20 mmol) in 50 mL of methanol was added 0.2 mL of concentrated sulfuric acid. The resulting solution was refluxed for 24 hours. Evaporation of the solvent gave a residue, which was redissolved into 100 mL of ethyl acetate. The organic layer was washed with saturated sodium biocarbonate solution, water and brine. The resulting organic layer was dried over sodium sulfate. Filtration off sodium sulfate and evaporation of the solvent gave methyl 2,5-dibromo-4-methylbenzoate as a white solid: 6.20 g (100%).

후처리

  1. temperatureThe resulting solution was refluxed for 24 hours
  2. customEvaporation of the solvent
  3. customgave a residue, which
  4. washThe organic layer was washed with saturated sodium biocarbonate solution, water and brine
  5. dry with materialThe resulting organic layer was dried over sodium sulfate
  6. filtrationFiltration
  7. customoff sodium sulfate and evaporation of the solvent

출처 및 근거

ORD 기록
ord-83edb0e976ef4969932a94916f9cc6dc
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044212B2

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