Bromine → 2-Bromo-1-[2-(trifluoromethyl)phenyl]ethan-1-one

HRID 1667651노트

반응식

HRID 1667651 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[O:11])[CH3:10].[Br:14]Br>ClCCl>[Br:14][CH2:10][C:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:12])([F:13])[F:1])=[O:11]

참가 물질

4

반응물 2

HCID 24408BromineHCID 870952'-(Trifluoromethyl)acetophenone

생성물 1

HCID 27784302-Bromo-1-[2-(trifluoromethyl)phenyl]ethan-1-one수율 92.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 20.00 g (0.11 mole) of 2′-(trifluoromethyl)acetophenone in 200 mL of dichloromethane was added 5.5 mL (0.11 mole) of bromine over 90 minutes. A stream of nitrogen was bubbled through the reaction mixture for 15 minutes. The mixture solvent was removed under reduced pressure. The residue was dissolved with ethanol, and then concentrated under reduced pressure to give 27.25 g of 2-bromo-1-(2-trifluoromethyl-phenyl)-ethanone as a yellow oil, which was used in the next step without further purification.

후처리

  1. customA stream of nitrogen was bubbled through the reaction mixture for 15 minutes
  2. customThe mixture solvent was removed under reduced pressure
  3. dissolutionThe residue was dissolved with ethanol
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-0b0a9f6db9024e3eb37d062e137f3e1f
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044213B2

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