Sulfuric Acid → 4-(4-trifluoromethyl-phenyl)-3H-thiazol-2-one
반응식
[S:1]([CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1)=O)[C:2]#[N:3].S(=O)(=O)(O)[OH:18]>C(O)(=O)C>[F:14][C:13]([F:16])([F:15])[C:10]1[CH:11]=[CH:12][C:7]([C:5]2[NH:3][C:2](=[O:18])[S:1][CH:4]=2)=[CH:8][CH:9]=1참가 물질
4
실험 절차
A mixture of 22.52 g (91.8 mmole) of 2-thiocyanato-1-(4-trifluoromethyl-phenyl)-ethanone 9 mL of 50% aqueous sulfuric acid and 45 mL of acetic acid was heated at reflux for 1.5 hours. The mixture was cooled, poured into 500 mL of ice water and stirred for 30 minutes. The solid was collected by filtration, washing with water, to give 21.33 g of 4-(4-trifluoromethyl-phenyl)-3H-thiazol-2-one as a tan solid.
후처리
- temperaturewas heated
- temperatureat reflux for 1.5 hours
- temperatureThe mixture was cooled
- filtrationThe solid was collected by filtration
- washwashing with water
출처 및 근거
- ORD 기록
- ord-73bbd9e4e1594d838e98bb1826b0a963
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08044213B2
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