Methanol → Methyl 3-(1-cyanoethyl)benzoate

HRID 1667847노트

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HRID 1667847 반응식
[C:1]([CH:3]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])[CH3:4])#[N:2].S(=O)(=O)(O)O.[CH3:19]O>>[C:1]([CH:3]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([O:10][CH3:19])=[O:9])[CH3:4])#[N:2]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 983703-(1-Cyanoethyl)benzoic acid

생성물 1

HCID 10035402Methyl 3-(1-cyanoethyl)benzoate수율 89%

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온도
60 °C

실험 절차

To a solution of 3-(1-cyanoethyl)benzoic acid (2.0 g, 11 mmol) in methanol (20 mL) was added conc. sulfuric acid (0.2 mL), and the mixture was stirred at 60° C. for 8 hr. The reaction mixture was concentrated under reduced pressure, and neutralized with saturated aqueous sodium hydrogencarbonate solution. The mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and filtrated. The solvent was evaporated under reduced pressure to give the title compound (1.9 g, 89%) as a colorless oil.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionThe mixture was diluted with water
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. filtrationfiltrated
  7. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-7f737523affb4866ac3945ba7b4e4f7a
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08044049B2

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